# Genetics

Source: https://onco.cc/fronts/da-front-genetics/  
OnCo record `da-front-genetics` (Front). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Genes can change risk and, rarely, cause familial disease. ApoE ε4 also changes antibody-safety counselling.

## Summary

Most dementia is not a single-gene disease. ApoE ε4 is a risk variant used in ARIA counselling, not a destiny. Autosomal-dominant Alzheimer’s disease and some FTD syndromes need genetics counselling, not a casual test.

## Fields

- Kind: Front
- Last checked: 2026-09-21
- Tags: dementia-atlas

## Sources

- NIA: Alzheimer’s genetics: https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet

## Connected records

- technologies: [ApoE testing](https://onco.cc/technologies/da-tech-apoe-testing/)
- diagnoses: [Frontotemporal dementia](https://onco.cc/diagnoses/frontotemporal-dementia/)

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