# Alpha-synuclein

Source: https://onco.cc/targets/da-target-alpha-synuclein/  
OnCo record `da-target-alpha-synuclein` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Alpha-synuclein is the protein in Lewy bodies. There is no approved treatment that clears it in dementia.

## Summary

Disease-modifying synuclein programmes are research, not standard care.

## Fields

- Kind: Target
- Last checked: 2026-09-21
- Tags: dementia-atlas
- Symbol: SNCA
- Class: other
- Biology: Presynaptic protein that aggregates in Lewy bodies.

## Sources

- Alzheimer’s Association: Lewy body: https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/dementia-with-lewy-bodies

## Connected records

- diagnoses: [Dementia with Lewy bodies](https://onco.cc/diagnoses/dementia-with-lewy-bodies/), [Parkinson’s disease dementia](https://onco.cc/diagnoses/parkinsons-disease-dementia/)

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JSON: https://onco.cc/api/v1/entities/da-target-alpha-synuclein.json