# Amyloid-beta

Source: https://onco.cc/targets/da-target-amyloid-beta/  
OnCo record `da-target-amyloid-beta` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Amyloid-beta is the protein fragment that forms plaques in Alzheimer’s disease. Clearing it is the idea behind several antibodies.

## Summary

Plaque reduction is now a measurable drug effect. Whether enough clinical benefit follows, for whom, is the practical question.

## Fields

- Kind: Target
- Last checked: 2026-09-21
- Tags: dementia-atlas
- Symbol: APP/Aβ
- Class: other
- Biology: Peptides from amyloid precursor protein that aggregate into plaques.
- Where found: Alzheimer’s disease cortex and vessel walls (CAA).

## Sources

- NIA: https://www.nia.nih.gov/health/alzheimers-and-dementia

## Connected records

- diagnoses: [Alzheimer’s disease](https://onco.cc/diagnoses/alzheimers-disease/)
- drugs: [Donanemab](https://onco.cc/drugs/da-donanemab/), [Lecanemab](https://onco.cc/drugs/da-lecanemab/), [Remternetug](https://onco.cc/drugs/da-remternetug/)
- pathways: [Amyloid and tau cascade (simplified)](https://onco.cc/pathways/da-pathway-amyloid-tau/)

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JSON: https://onco.cc/api/v1/entities/da-target-amyloid-beta.json