# Tau

Source: https://onco.cc/targets/da-target-tau/  
OnCo record `da-target-tau` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Tau is the tangle protein. Its spread tracks symptoms more closely than plaques in many studies.

## Summary

Tau therapeutics remain investigational. MAPT mutations are a rare genetic FTD cause.

## Fields

- Kind: Target
- Last checked: 2026-09-21
- Tags: dementia-atlas
- Symbol: MAPT
- Class: other
- Biology: Microtubule-associated protein that forms neurofibrillary tangles when hyperphosphorylated.

## Sources

- NIA: https://www.nia.nih.gov/health/alzheimers-and-dementia

## Connected records

- diagnoses: [Alzheimer’s disease](https://onco.cc/diagnoses/alzheimers-disease/), [Frontotemporal dementia](https://onco.cc/diagnoses/frontotemporal-dementia/)
- fronts: [Anti-tau research](https://onco.cc/fronts/da-front-anti-tau/)
- technologies: [Tau-directed therapeutics](https://onco.cc/technologies/da-tech-tau-therapeutics/)
- pathways: [Amyloid and tau cascade (simplified)](https://onco.cc/pathways/da-pathway-amyloid-tau/)

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JSON: https://onco.cc/api/v1/entities/da-target-tau.json