# TDP-43

Source: https://onco.cc/targets/da-target-tdp43/  
OnCo record `da-target-tdp43` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

TDP-43 is a protein involved in some frontotemporal and related diseases. It is a research target, not a licensed treatment.

## Summary

Pathology helps explain FTD heterogeneity. It does not yet yield an approved medicine.

## Fields

- Kind: Target
- Last checked: 2026-09-21
- Tags: dementia-atlas
- Symbol: TARDBP
- Class: other
- Biology: RNA-binding protein that mislocalises in some FTD and related diseases.

## Sources

- NIA: FTD: https://www.nia.nih.gov/health/alzheimers-and-dementia/frontotemporal-disorders

## Connected records

- diagnoses: [Frontotemporal dementia](https://onco.cc/diagnoses/frontotemporal-dementia/)

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JSON: https://onco.cc/api/v1/entities/da-target-tdp43.json