{"entity":{"id":"da-brexpiprazole","kind":"drug","name":"Brexpiprazole","aka":[],"tldr":"Brexpiprazole has a US indication for agitation in Alzheimer’s dementia after other causes are considered. Antipsychotics increase mortality in elderly people with dementia-related psychosis.","summary":"It is not an as-needed sedative. Boxed warning: antipsychotics increase mortality in elderly people with dementia-related psychosis. Look first for pain, delirium, and unmet need.","status":"approved","asOf":"2026-09-21","links":[{"label":"FDA agitation approval","url":"https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-treat-agitation-symptoms-associated-dementia-due-alzheimers-disease"}],"tags":["dementia-atlas"],"related":[],"cancers":["alzheimers-disease"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"Rexulti","modality":"small molecule","mechanism":"Antipsychotic used for agitation associated with dementia due to Alzheimer’s disease. It does not treat memory loss.","approvals":[{"region":"US","year":2023,"indication":"Agitation associated with dementia due to Alzheimer’s disease"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/da-brexpiprazole/","neighbours":{"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"}]}}