{"entity":{"id":"da-front-genetics","kind":"section","name":"Genetics","aka":[],"tldr":"Genes can change risk and, rarely, cause familial disease. ApoE ε4 also changes antibody-safety counselling.","summary":"Most dementia is not a single-gene disease. ApoE ε4 is a risk variant used in ARIA counselling, not a destiny. Autosomal-dominant Alzheimer’s disease and some FTD syndromes need genetics counselling, not a casual test.","asOf":"2026-09-21","links":[{"label":"NIA: Alzheimer’s genetics","url":"https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet"}],"tags":["dementia-atlas"],"related":["da-tech-apoe-testing"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"order":3},"route":"/fronts/da-front-genetics/","neighbours":{"technology":[{"id":"da-tech-apoe-testing","kind":"technology","name":"ApoE testing","route":"/technologies/da-tech-apoe-testing/"}],"cancer":[{"id":"frontotemporal-dementia","kind":"cancer","name":"Frontotemporal dementia","route":"/diagnoses/frontotemporal-dementia/"}]}}