{"entity":{"id":"da-idea-blood-first-triage","kind":"idea","name":"Blood test before PET or lumbar puncture","aka":[],"tldr":"Use a blood test to decide who still needs a scan or spinal-fluid test, instead of sending everyone to PET.","summary":"This is a proposed clinic pathway, not a licensed consumer diagnosis. The test has to beat sending everyone, and it has to fail safe.","asOf":"2026-09-21","links":[{"label":"NIA","url":"https://www.nia.nih.gov/health/alzheimers-and-dementia"}],"tags":["dementia-atlas"],"related":[],"cancers":["alzheimers-disease","mild-cognitive-impairment"],"sections":[],"technologies":["da-tech-blood-biomarkers"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":["da-bn-late-diagnosis"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hypothesis":"A validated plasma assay can reserve amyloid PET and CSF for people whose blood result is intermediate or whose clinical picture still needs confirmation.","rationale":"PET and lumbar puncture are accurate but scarce. A blood-first path could shorten waits if false reassurance is controlled.","test":"Prospective memory-clinic study: plasma assay then PET or CSF reference, with pre-specified sensitivity for a negative blood test and a decision-impact endpoint (fewer unnecessary scans without missed antibody candidates).","maturity":"early-clinical","actor":"clinic","cost":"medium","horizonYears":5},"route":"/ideas/da-idea-blood-first-triage/","neighbours":{"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"},{"id":"mild-cognitive-impairment","kind":"cancer","name":"Mild cognitive impairment","route":"/diagnoses/mild-cognitive-impairment/"}],"technology":[{"id":"da-tech-blood-biomarkers","kind":"technology","name":"Blood Alzheimer biomarkers","route":"/technologies/da-tech-blood-biomarkers/"}],"bottleneck":[{"id":"da-bn-late-diagnosis","kind":"bottleneck","name":"Late and uneven diagnosis","route":"/bottlenecks/da-bn-late-diagnosis/"}],"roadmap":[{"id":"da-roadmap-anti-amyloid","kind":"roadmap","name":"Anti-amyloid medicines","route":"/roadmaps/da-roadmap-anti-amyloid/"}]}}