{"entity":{"id":"da-target-ache","kind":"target","name":"Acetylcholinesterase","aka":[],"tldr":"Blocking this enzyme is how donepezil, rivastigmine, and galantamine try to support signalling.","summary":"The approach is symptomatic. It does not clear plaques or tangles.","asOf":"2026-09-21","links":[{"label":"NICE NG97","url":"https://www.nice.org.uk/guidance/ng97"}],"tags":["dementia-atlas"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["da-donepezil","da-rivastigmine","da-galantamine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"ACHE","biology":"Enzyme that breaks down acetylcholine in the synaptic cleft.","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/da-target-ache/","neighbours":{"drug":[{"id":"da-donepezil","kind":"drug","name":"Donepezil","route":"/drugs/da-donepezil/"},{"id":"da-galantamine","kind":"drug","name":"Galantamine","route":"/drugs/da-galantamine/"},{"id":"da-rivastigmine","kind":"drug","name":"Rivastigmine","route":"/drugs/da-rivastigmine/"}],"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"},{"id":"dementia-with-lewy-bodies","kind":"cancer","name":"Dementia with Lewy bodies","route":"/diagnoses/dementia-with-lewy-bodies/"},{"id":"parkinsons-disease-dementia","kind":"cancer","name":"Parkinson’s disease dementia","route":"/diagnoses/parkinsons-disease-dementia/"}]}}