{"entity":{"id":"frontotemporal-dementia","kind":"cancer","name":"Frontotemporal dementia","aka":[],"tldr":"Frontotemporal dementia often changes behaviour, personality, or language earlier than memory. There is no FDA-approved medicine specifically for its cognitive symptoms.","summary":"Frontotemporal dementia (FTD) includes behavioural-variant and language-led presentations. Pathology may involve tau or TDP-43. Memory can be relatively spared early, which delays recognition. There is no FDA-approved cognitive treatment for FTD. Psychiatric or behavioural medicines, when used, are for separate indications and need specialist judgement. Treating the wrong subtype can add harm without benefit.","asOf":"2026-09-21","wikipedia":"https://en.wikipedia.org/wiki/Frontotemporal_dementia","links":[{"label":"NIA: frontotemporal disorders","url":"https://www.nia.nih.gov/health/alzheimers-and-dementia/frontotemporal-disorders"}],"tags":["dementia-atlas"],"related":["dementia","alzheimers-disease"],"cancers":[],"sections":["da-front-symptomatic-care","da-front-genetics"],"technologies":[],"targets":["da-target-tau","da-target-tdp43"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":["da-bn-subtype-misclassification"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"group":"dementia","subtypes":[],"biomarkers":[],"standardOfCare":[],"stateOfArt":[],"history":[],"pipeline":[],"openProblems":[],"parent":"dementia"},"route":"/diagnoses/frontotemporal-dementia/","neighbours":{"cancer":[{"id":"alzheimers-disease","kind":"cancer","name":"Alzheimer’s disease","route":"/diagnoses/alzheimers-disease/"},{"id":"dementia","kind":"cancer","name":"Dementia (umbrella)","route":"/diagnoses/dementia/"}],"section":[{"id":"da-front-genetics","kind":"section","name":"Genetics","route":"/fronts/da-front-genetics/"},{"id":"da-front-symptomatic-care","kind":"section","name":"Symptomatic care","route":"/fronts/da-front-symptomatic-care/"}],"target":[{"id":"da-target-tau","kind":"target","name":"Tau","route":"/targets/da-target-tau/"},{"id":"da-target-tdp43","kind":"target","name":"TDP-43","route":"/targets/da-target-tdp43/"}],"bottleneck":[{"id":"da-bn-subtype-misclassification","kind":"bottleneck","name":"Wrong-subtype treatment","route":"/bottlenecks/da-bn-subtype-misclassification/"}]}}