[{"id":"retinoblastoma","kind":"cancer","name":"Retinoblastoma","route":"/cancers/retinoblastoma/","commit":"28a6975696","date":"2026-09-10","author":"Jude Gomila","message":"Tone pass: solution and mechanism first; frightening figures behind a click","file":"src/data/spikes/gap-cancers.ts","type":"changed","fields":[{"field":"tldr","before":"\"An eye cancer of infants caused by loss of the RB1 gene, the first tumour-suppressor gene ever found. In rich countries almost every child survives and most eyes are saved by chemotherapy delivered through the eye's ...","after":"\"An eye cancer of infants caused by loss of the RB1 gene, the first tumour-suppressor gene ever found. In rich countries almost every child survives and most eyes are saved by chemotherapy delivered through the eye's ..."},{"field":"summary","before":"\"Retinoblastoma arises from biallelic loss of RB1 in developing retinal cells (Knudson's two-hit hypothesis, 1971; RB1 cloned 1986), or rarely from MYCN amplification with intact RB1. Heritable disease (~40%, germline...","after":"\"Retinoblastoma arises from biallelic loss of RB1 in developing retinal cells (Knudson's two-hit hypothesis, 1971; RB1 cloned 1986), or rarely from MYCN amplification with intact RB1. Heritable disease (~40%, germline..."},{"field":"standardOfCare","before":"[\n      { setting: \"Advanced unilateral (group E, no vision potential)\", approach: \"Primary enucleation with long optic nerve segment; adjuvant chemotherapy (VEC) for high-risk pathology; orbital implant.\", refs: [\"vi...","after":"[\n      { setting: \"Advanced unilateral (group E, no vision potential)\", approach: \"Primary enucleation with long optic nerve segment; adjuvant chemotherapy (VEC) for high-risk pathology; orbital implant.\", refs: [\"vi..."},{"field":"stateOfArt","before":"[\"Intra-arterial chemotherapy saves eyes that would have been removed, with globe salvage ~70-90% in group D and few systemic effects.\", \"Radiation has been almost eliminated because of second cancers in RB1 carriers....","after":"[\"Intra-arterial chemotherapy saves eyes that would have been removed, with globe salvage ~70-90% in group D and few systemic effects.\", \"Radiation has been almost eliminated because of second cancers in RB1 carriers...."},{"field":"openProblems","before":"[\"Late diagnosis and death in low-income countries; paediatric ophthalmology access.\", \"Second primary cancers in RB1 carriers across life.\", \"Vision outcomes after eye salvage.\", \"Metastatic and CNS disease.\"]","after":"[\"Late diagnosis in low-income countries; paediatric ophthalmology access is the lever.\", \"Second primary cancers in RB1 carriers across life.\", \"Vision outcomes after eye salvage.\", \"Metastatic and CNS disease.\"]"}]},{"id":"retinoblastoma","kind":"cancer","name":"Retinoblastoma","route":"/cancers/retinoblastoma/","commit":"71e4eef6e1","date":"2026-09-08","author":"Jude Gomila","message":"Gap audit and gap-fill data: 33 cancers, 87 products, 20 targets, 25 technologies, 12 terms, 18 collections","file":"src/data/spikes/gap-cancers.ts","type":"added","fields":[{"field":"id"},{"field":"name"},{"field":"group"},{"field":"wikipedia"},{"field":"burden"},{"field":"tldr"},{"field":"summary"},{"field":"subtypes"},{"field":"biomarkers"},{"field":"standardOfCare"},{"field":"stateOfArt"},{"field":"history"},{"field":"pipeline"},{"field":"openProblems"},{"field":"targets"},{"field":"technologies"},{"field":"drugs"},{"field":"pathways"},{"field":"institutions"},{"field":"terms"},{"field":"links"},{"field":"tags"}]}]