Target
Acetylcholinesterase
Blocking this enzyme is how donepezil, rivastigmine, and galantamine try to support signalling.
Target
Alpha-synuclein
Alpha-synuclein is the protein in Lewy bodies. There is no approved treatment that clears it in dementia.
Target
Amyloid-beta
Amyloid-beta is the protein fragment that forms plaques in Alzheimer’s disease. Clearing it is the idea behind several antibodies.
Target
Tau
Tau is the tangle protein. Its spread tracks symptoms more closely than plaques in many studies.
Target
TDP-43
TDP-43 is a protein involved in some frontotemporal and related diseases. It is a research target, not a licensed treatment.