Acetylcholinesterase
Blocking this enzyme is how donepezil, rivastigmine, and galantamine try to support signalling.
Overview
The approach is symptomatic. It does not clear plaques or tangles.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · Blocking this enzyme is how donepezil, rivastigmine, and galantamine try to support signalling.
- 1 · What it is
Blocking this enzyme is how donepezil, rivastigmine, and galantamine try to support signalling.
- 2 · What goes wrong in cancer
Enzyme that breaks down acetylcholine in the synaptic cleft.
- 3 · How drugs use it
3 products aim at Acetylcholinesterase: small molecules. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Biology
Enzyme that breaks down acetylcholine in the synaptic cleft.
Donepezil is a tablet used for cognitive symptoms in Alzheimer’s disease. It may help some people a little. It does not slow the disease itself.
Galantamine is a tablet for mild-to-moderate dementia of the Alzheimer’s type. It is not approved for vascular, frontotemporal, or Lewy body dementia.
Rivastigmine is used for Alzheimer’s dementia and has a US indication for dementia associated with Parkinson’s disease. It is a symptom treatment.
Latest papers
topQuery for this target: (TITLE:"Acetylcholinesterase" OR ABSTRACT:"Acetylcholinesterase" OR TITLE:"ACHE" OR ABSTRACT:"ACHE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Acetylcholinesterase, not a curated reading list.
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