Tau

Tau is the tangle protein. Its spread tracks symptoms more closely than plaques in many studies.

Tau therapeutics remain investigational. MAPT mutations are a rare genetic FTD cause.

Tau: what it is and how drugs act on it · animated generic schematic, not to scale

In plain words · Tau is the tangle protein. Its spread tracks symptoms more closely than plaques in many studies.

1 · What it is
Tau is the tangle protein. Its spread tracks symptoms more closely than plaques in many studies.
2 · What goes wrong in cancer
Microtubule-associated protein that forms neurofibrillary tangles when hyperphosphorylated.
3 · How drugs use it
No product in this corpus aims at Tau yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.

External identifiers

Microtubule-associated protein that forms neurofibrillary tangles when hyperphosphorylated.

Where it is found

Class

other · MAPT

Target
Amyloid-beta
Shares Amyloid and tau cascade (simplified), Alzheimer’s disease and the tag dementia-atlas.
Target
TDP-43
Shares Frontotemporal dementia and the tag dementia-atlas.
Bottleneck
Wrong-subtype treatment
Shares Frontotemporal dementia, Alzheimer’s disease and the tag dementia-atlas.
Person
Alois Alzheimer
Shares Alzheimer’s disease and the tag dementia-atlas.
Treatment
Brexpiprazole
Shares Alzheimer’s disease and the tag dementia-atlas.
Collection
ClinicalTrials.gov
Shares Alzheimer’s disease and the tag dementia-atlas.
Treatment
Memantine
Shares Alzheimer’s disease and the tag dementia-atlas.
Institution
National Institute on Aging
Shares Alzheimer’s disease and the tag dementia-atlas.

Evidence strength0/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Formula disclosed on the evidence page.

Not yet reviewedNeeds expert (scientific) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Sources & links